1/17/2024 0 Comments Science daily genetics![]() She started by plotting the difference in frequency of the rare variants, and quickly realized that there was a significant reduction in prevalence of the variants in African Americans. Astore used that database to conduct her analysis. In a collaboration with Subra Kugathasan from Emory University and the NIH's IBD Genetics Consortium, Gibson's lab had analyzed the complete genome sequences of over 3,000 genomes of African Americans, half with IBD. student in Gibson's lab and first author on the paper, wanted to assess whether those same rare variants would have a similar effect on IBD risk in African Americans. But progression is often much worse: African Americans are more likely to progress to severe disease requiring colectomies and other major interventions.Ĭourtney Astore, a Ph.D. Today, African Americans have a similar prevalence of various types of IBD as European Americans. "Understanding whether genetic differences contribute to health disparities is a major point of focus for current genetics research, and we had an opportunity to test one idea with this study." ![]() "Because of major advancements in the last decade, we now know that most diseases are far more complex than we originally thought, in terms of genetics," said Gibson, who is also director of the Center for Integrative Genomics at Georgia Tech. The findings were published in the journal Genome Medicine. Led by Greg Gibson, Regents' Professor and Tom and Marie Patton Chair in the School of Biological Sciences, the study highlights the importance of considering genetic diversity and the mixing of ancestry in genetics research. While the rare variant associations were recently discovered in individuals of European ancestry, contributing to about 15% of cases, it was unknown if and how those same rare gene variants might affect risk for African Americans. In a new study, Georgia Tech researchers investigated whether 25 rare gene variants known to be associated with inflammatory bowel disease (IBD) play a role in risk for African Americans.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |